The use of a patient’s or tumor’s DNA sequence to diagnose/characterize a disease and select or discover drugs that have the highest likelihood of response with least toxicity is one way of broadly defining Precision Medicine. Although most doctors would agree that medicine is far from precise, President Obama’s state of the union address in early 2015 made ‘precision medicine’ a household phrase drawing public attention to this burgeoning field. Mayo clinic has adopted the phrase individualized medicine in naming its world class center at Rochester, MN. Some even refer to it as genomic medicine but I like ‘personalized medicine’ (PM) better. Major healthcare organizations in US and around the world are early adopters and are already practicing PM.