The Pentagon’s research and development division, DARPA—the creative force behind the internet and GPS—retooled itself three years ago to create a new office dedicated to unraveling biology’s engineering secrets. The new Biological Technologies Office (BTO) has a mission to “harness the power of biological systems” and design new defense technology. Over the past year, with a budget of about $296 million, it has been exploring challenges including memory improvement, human–machine symbiosis and speeding up disease detection and response.