A Whiting School-led interinstitutional research team will develop a novel photoacoustic endoscope and fluorescent contrast agent to ensure total tumor removal and preservation of healthy tissue
A Johns Hopkins Engineering-led team has won an award of up to $20.9 million over five years from the Advanced Research Projects Agency for Health (ARPA-H) to develop novel technologies for precise tumor removal. ARPA-H is a federal funding agency established by the Biden-Harris administration to rapidly advance high-impact biomedical research centered around preventing, detecting, and treating cancer and other diseases.
Using its ARPA-H award, the team, led by Emad Boctor of the Whiting School of Engineering and including collaborators from Johns Hopkins’ schools of Engineering and Medicine, the University of Texas Southwestern Medical Center, the National Institutes of Health Clinical Center, and industry will develop a novel, non-contact photoacoustic endoscope that promises to provide an information-enhanced view of the surgical field without altering surgeons’ workflows. When used with the team’s proposed multi-cancer fluorescent contrast agent, the endoscope will help surgeons identify and remove any remaining microscopic cancer remnants during tumor removal procedures.
The team will also use existing fluorescent dyes in combination with their novel photoacoustic endoscope to visualize critical anatomical structures, allowing surgeons to “see” deep into human tissue to reveal hidden blood vessels and nerves so that they are not accidentally damaged during such procedures.
This project is one of several nationwide chosen for funding of up to $150 million total from the ARPA-H Precision Surgical Interventions (PSI) program, which is part of the broader Biden-Harris administration’s Cancer Moonshot initiative.
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