AstraZeneca will jointly develop and commercialize its high-risk, Phase II/III-bound Alzheimer’s disease drug candidate AZD3293 with Eli Lilly, in a deal that could net AZ up to $500 million in development and regulatory milestone payments.
AZD3293 is an oral beta secretase cleaving enzyme (BACE) inhibitor designed to prevent the formation of amyloid plaque and eventually slow the progression of Alzheimer’s. The company cites Phase I studies that showed AZD3293 significantly and dose-dependently reduced levels of amyloid beta in the cerebro-spinal fluid of Alzheimer’s patients and healthy volunteers.
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